18F-Labelled Intermediates for Radiosynthesis by Modular Build-Up Reactions: Newer Developments

This brief review gives an overview of newer developments in (18)F-chemistry with the focus on small (18)F-labelled molecules as intermediates for modular build-up syntheses. The short half-life (<2 h) of the radionuclide requires efficient syntheses of these intermediates considering that multistep syntheses are often time consuming and characterized by a loss of yield in each reaction step. Recent examples of improved synthesis of (18)F-labelled intermediates show new possibilities for no-carrier-added ring-fluorinated arenes, novel intermediates for tri[(18)F]fluoromethylation reactions, and (18)F-fluorovinylation methods.